Basic Information English Name: 2-Nitrophenol  Synonyms: o-Nitrophenol; 2-Hydroxynitrobenzene  CAS No.: 88-75-5  EINECS No.: 201-857-5  Molecular Formula: \(C_6H_5NO_3\)  Molecular Weight: 139.11  Physical and Chemical Properties Appearance: Light yellow crystalline powder  Odor: Almond-like odor  Melting Point: 43 - 47°C  Boiling Point: 214 - 216°C  Relative Density: 1.495 (water = 1)  Solubility: Soluble in ethanol, ether, benzene, carbon disulfide, alkali hydroxide solutions and hot water. Slightly soluble in cold water. It can volatilize with steam. Toxicological Data Acute Toxicity: LD50 for rats by oral administration is 334 mg/kg13.  Irritation: It has a strong irritating effect on the skin and can be absorbed through the skin and respiratory tract. Animal experiments have shown that it can cause methemoglobinemia, elevated body temperature, and liver and kidney damage135.  Ecological Data1 Ecotoxicity: LC50 is 100 mg/L (48h) for medaka and 210 mg/L (24h) for Daphnia magna.  Biodegradability: Aerobic biodegradation takes 168 - 672 h, and anaerobic biodegradation takes 168 - 672 h.  Abiotic Degradability: The half-life of photolysis in the aqueous phase is 230 - 408 h, and the half-life of photooxidation in the air is 7 - 71 h. Preparation Methods Hydrolysis Method: Using o-nitrochlorobenzene as the raw material, it undergoes hydrolysis with sodium hydroxide solution at a pressure of 0.2 - 0.4 MPa and a temperature of 130 - 150°C. After the reaction, it is acidified with sulfuric acid, cooled, crystallized and centrifugally separated to obtain the finished product.  Nitration Method: Using phenol as the raw material, it is nitrated with nitric acid to obtain a mixture of p-nitrophenol and o-nitrophenol. Then, it is steam-distilled, cooled, crystallized and centrifugally separated to obtain the finished product.  Uses In the Pharmaceutical Industry: It is used to prepare drugs such as phenacetin and paracetamol1.  In the Dye Industry: It is used as an intermediate to produce sulfur dyes, such as sulfur grass green GN, sulfur reduction black CL, etc1.  Other Applications: It is used as an analytical reagent and a single-color pH indicator. It is also a raw material for the organophosphorus insecticides parathion and methyl parathion in pesticides. In addition, it can be used to manufacture photographic materials such as the developer metol1.  Safety Information1 Dangerous Goods Label: Xn (Harmful)  Risk Codes: 22-36/37/38-52/53-33-20/21/22-39/23/24/25-23/24/25-11  Safety Instructions: 26-61-45-36/37-16-7-36-28  Dangerous Goods Transport Number: UN 1663 6.1/PG 3

Safety Data Sheet for Hydrazine Hydrate 1. Identification of the Substance/Chemical Product Product Name: Hydrazine Hydrate Synonyms: Dihydrazine monoxide; Hydrazine, monohydrate CAS Number: 7803-57-8 Product Use: Widely used in various industries such as pharmaceuticals, agrochemicals, and as a reducing agent in chemical reactions. 2. Composition/Information on Ingredients Chemical Name: Hydrazine Hydrate CAS Number: 7803-57-8 Concentration: Usually available in different concentrations, such as 50%, 64%, etc. 3. Hazards Identification Physical and Chemical Hazards: Flammable liquid. Vapors can form explosive mixtures with air. Health Hazards: Highly toxic. Inhalation, ingestion, or skin contact can cause severe damage to the central nervous system, liver, and kidneys. It is also a probable human carcinogen. Environmental Hazards: Harmful to aquatic life with long - lasting effects. 4. First - Aid Measures Inhalation: Remove the victim to fresh air immediately. If breathing is difficult, give oxygen. Seek medical attention immediately. Skin Contact: Remove contaminated clothing and wash the affected area with plenty of soap and water for at least 15 minutes. Seek medical advice. Eye Contact: Flush eyes with plenty of water for at least 15 minutes, lifting the eyelids occasionally. Get medical treatment immediately. Ingestion: Do not induce vomiting. Give the victim water to drink. Seek immediate medical attention. 5. Fire - Fighting Measures Suitable Extinguishing Media: Use dry chemical, carbon dioxide, or foam extinguishers. Special Hazards: When heated, it decomposes to form toxic and flammable gases. Firefighters should wear self - contained breathing apparatus and full protective clothing. 6. Accidental Release Measures Personal Precautions: Evacuate the area immediately. Wear appropriate personal protective equipment, including chemical - resistant gloves, goggles, and a respirator. Environmental Precautions: Prevent the release from entering waterways, sewers, or soil. Clean - up Methods: Absorb the spill 7. Handling and Storage Handling: Handle in a well - ventilated area. Avoid contact with skin, eyes, and clothing. Use appropriate engineering controls to minimize exposure. Do not smoke or have open flames in the vicinity. Storage: Store in a cool, dry, well - ventilated area away from oxidizing agents, acids, and other incompatible substances. Keep containers tightly closed. 8. Exposure Controls/Personal Protection Engineering Controls: Use local exhaust ventilation to keep airborne concentrations below the exposure limits. Personal Protective Equipment: Respiratory Protection: Use a respirator approved for use with hydrazine hydrate in case of potential exposure. Eye Protection: Wear chemical - splash goggles. Skin Protection: Wear chemical - resistant gloves and protective clothing. 9. Physical and Chemical Properties Appearance: Colorless, fuming liquid with a strong, ammonia - like odor. Melting Point: -51.7 °C Boiling Point: 118.5 °C Density: 1.032 g/cm³ (at 20 °C) Solubility: Miscible with water, alcohol, and ammonia. 10. Stability and Reactivity Stability: Stable under normal conditions. Incompatible Materials: Strong oxidizing agents, acids, metal salts. Hazardous Decomposition Products: When heated or in contact with incompatible substances, it decomposes to form nitrogen, ammonia, and other toxic gases. 11. Toxicological Information Acute Toxicity: High acute toxicity. LD50 (oral, rat): 60 mg/kg. Carcinogenicity: Listed as a probable human carcinogen by IARC. Other Toxic Effects: Can cause damage to the liver, kidneys, and central nervous system. 12. Ecological Information Ecotoxicity: Toxic to aquatic organisms. Persistence and Degradability: Slowly biodegradable. Bioaccumulation Potential: May bioaccumulate in the food chain. 13. Disposal Considerations Waste Disposal Method: Dispose of in accordance with local, regional, national, and international regulations. Do not discharge into the environment. Contact a licensed waste disposal company for proper disposal. 14. Transport Information UN Number: 2030 Proper Shipping Name: Hydrazine Hydrate Hazard Class: 8 (Corrosive) and 6.1 (Toxic) Packing Group: II 15. Regulatory Information Regulatory Status: Subject to various regulations regarding its use, storage, and disposal due to its toxicity and environmental hazards. 16. Other Information Revision Date: [Date of the latest revision] Prepared by: [Name of the company or department preparing the SDS] This Safety Data Sheet is provided for information purposes only. It is the responsibility of the user to ensure compliance with all relevant safety regulations and to use the product safely.

1.Technological innovation is the core driving force for the development of hydrazine hydrate industry in China. With the development of related industries and technological progress, the production process of hydrazine hydrate is constantly optimized. Enterprises increase investment in research and development, introduce advanced technology and talents, and develop new products to meet the diversified needs of the market. For example, mainstream production processes such as ketozine and hydrogen peroxide have been continuously improved to improve product quality and purity. At the same time, technological innovation is also reflected in reducing energy consumption and reducing emissions, achieving green development, such as developing more efficient catalysts to improve reaction efficiency, reducing energy consumption and waste emissions in the production process. 2.The strengthening of environmental protection policies has brought new opportunities and challenges to the development of hydrazine hydrate market. With the increasing attention of the state to environmental protection, the environmental protection requirements in the production process of hydrazine hydrate are becoming more and more stringent. On the one hand, this encourages enterprises to increase investment in environmental protection, improve production technology and process, adopt more environmentally friendly production methods, reduce the impact on the environment, such as the use of green synthesis methods, reduce waste emissions, etc. On the other hand, some backward production capacity that cannot meet the requirements of environmental protection will be eliminated, and the market supply structure will be further optimized. At the same time, in the field of environmental protection, the application of hydrazine hydrate as a water treatment agent may be further expanded with the development of environmental protection industry. 3.Hydrazine hydrate as an important chemical raw material, in the traditional aerospace, medicine, pesticides, dyes and polymer synthesis and other fields of demand will continue to remain stable. At the same time, with the continuous progress of science and technology, in some emerging areas, such as high-tech materials and new energy fields, the demand for hydrazine hydrate is expected to increase. For example, in the development and production of new battery materials, hydrazine hydrate may play a new role, thus opening up new market space. In addition, hydrazine hydrate is a global market product, the future development of the industry is not limited to developed countries, in emerging markets, especially Asia and Latin America and other regions, the demand for hydrazine hydrate growth potential is huge, the market will further expand to the world.

Basic Information Synonyms : 2-Aminophenol,2-Amino-1-hydroxybenzene, 2-Hydroxyaniline, o-Hydroxyaniline, etc. CAS No.:95-55-6 Molecular Formula: C6H,NO Molecular Weight:109.12588 1 Physical Properties Appearance: Pure o-aminophenol is a white acicular crystal, which turns brown or black when exposed to light and air for a long time. Melting Point:172-177℃ Boiling Point: 164 ℃ (11 mmHg) Density: 1.328 Flash Point: 168℃ Solubility: Soluble in water, ethanol and ether, slightly soluble in benzene. Chemical Properties Stability:It is stable, but may be sensitive to air and light. It is incompatible with strong oxidizing agents and acids. Reaction with Inorganic Acids : It can react with inorganic acids to form water-soluble salts. Reaction with Ferric Chloride: It turns red when reacting with ferric chloride. Uses   Dye Industry: It is mainly used as an intermediate for organic synthesis and dyes, and is used to produce sulfur dyes, azo dyes, fur dyes such as fur yellow A, acid mordant blue R, sulfur yellow brown, fluorescent brightener EBF, etc. Pharmaceutical Industry: It can be used to synthesize some drugs. . Other Fields: It is used as a plastic curing agent and as a reagent for the determination of gold and silver.

4,4'-Diaminodiphenyl ether is an important organic compound with the molecular formula . It is also known as ODA for short.   Physical Properties: It appears as white to light yellow crystals or powder. It has a melting point in the range of about 189 - 191 °C. It is sparingly soluble in common organic solvents such as ethanol and acetone, and has poor solubility in water. Chemical Properties: The two amino groups  on the molecule of 4,4'-Diaminodiphenyl ether are of great chemical activity. It can undergo various chemical reactions such as acylation, alkylation and condensation reactions. Due to the existence of the ether bond , the molecule has certain stability, but it can also be cleaved under certain strong acid or strong base conditions. Synthesis: It is usually synthesized by the reaction of 4-nitrophenol and 4-nitrochlorobenzene to form 4,4'-dinitrodiphenyl ether, followed by reduction of the nitro groups to amino groups using reducing agents such as iron powder and hydrochloric acid or hydrogen in the presence of a catalyst. Applications: It is widely used in the synthesis of high-performance polymers. For example, it is an important monomer for the synthesis of polyimides, which have excellent thermal stability, mechanical properties and electrical insulation properties and are widely used in the aerospace, electronics and other industries. In addition, it can also be used as an intermediate in the synthesis of some dyes, pesticides and pharmaceutical products, playing an important role in the fields of fine chemical industry. Safety: 4,4'-Diaminodiphenyl ether may cause certain harm to human health. It may cause skin irritation, eye irritation and respiratory irritation. Long-term or excessive exposure may have potential toxic effects on the body, so appropriate protective measures should be taken when handling it.

Clinical use Ibuprofen is a non-steroidal anti-inflammatory drug, its anti-inflammatory, analgesic and antipyretic effects are 16 to 32 times stronger than aspirin. Ibuprofen is suitable for the treatment of rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, neuritis, pharyngitis and bronchitis. Executive standard Implement current USP, EP, BP, CP standards and customer specific standards. Specification packaging form 15kg, 25kg, 80kg, 100kg/cardboard drum

Clinical use Aspirin has the effects of salicylic acid analgesia, anti-inflammatory, antipyretic, anti-rheumatic and platelet aggregation. It can be used in the following situations: a. Analgesia and antipyretic. b. Anti-inflammatory, anti-rheumatic. c. Arthritis. d. Antithrombotic. Executive standard CP, BP, EP, USP Specification packaging form 25kg/composite woven bag; 25kg, 50kg, 100kg/cardboard drum; 800kg, 1000kg/bag, woven bag

Clinical use Glimemide is a sulfonylurea oral hypoglycemic agent whose main mechanism of hypoglycemic action is to stimulate insulin for type II (non-islet dependent) diabetes. It is a new generation (third generation) sulfonylurea oral hypoglycemic agent. Executive standard Cp, usp Specification packaging form Bulk packaging cardboard drum

Clinical use Meloxicam is a non-steroidal anti-inflammatory drug of enolic acid, which is suitable for the treatment of painful osteoarthritis (arthritic degenerative osteoarthrosis) for the symptoms of rheumatoid arthritis (antipyretic and analgesic, Anti-inflammatory, rheumatoid) Executive standard CP/ BP Specification packaging form 20kg/cardboard barrel

Clinical use Adrenal corticosteroids have effects on glucose metabolism, anti-inflammatory, anti-allergic, anti-toxic, etc., and are mainly used as an alternative treatment for adrenal insufficiency. Executive standard USP, BP, EP, CP and customer standards Specification packaging form 5kg/barrel, 10kg/barrel, 25kg/barrel cardboard drum